Methylation is a biochemical reaction taking place in every cell millions of times a day. It is dependent on the nutrients B6, B12, and Folic acid being available and activated in the body. If these nutrients are in short supply due to poor diet, poor absorption or a genetic inability to activate them, then methylation will be inhibited with detrimental effects in diverse aspects of health and wellbeing. Two genetic polymorphisms which can inhibit methylation are Pyrroluria (deficient in active B6 and zinc) & the MTHFR gene (can’t activate Folic Acid). Simple tests are available for both of these conditions. Methylation is needed for:
- Copying and repairing DNA
- Switching genes on or off
- Detoxification in the Liver
- Controlling mood via manufacture of Neurotransmitters
- Maintaining integrity of the Myelin sheath which coats nerves
- Manufacturing energy in mitochondria (the cells energy factory)
- Histamine regulation associated with allergies